Red Devils will look to secure qualification to the next round and will be wary of not showing complacency ahead of the Manchester derby.
The Red Devils go into the European tie following their enthralling 3-1 victory over Arsenal.
Despite leading Group A on 12 points, United have not yet mathematically qualified for the round of 16. A draw would be enough for the Red Devils to top the group.
If Basel fail to beat Benfica in the group’s other match, United would qualify regardless of their own result.
Moscow come into this one in good form, having won five and drawn one of their last six matches in all competitions.
Viktor Goncharenko’s side recorded their biggest victory since April 2016 on Friday night, beating FC Tosno 6-0 at home.
Manchester United were devastating in front of goal on Saturday, beating Arsenal 3-1 at the Emirates.
Man United team news vs CSKA Moscow
Paul Pogba is likely to feature, given that he’ll be unavailable for the next three domestic matches after being sent off at Arsenal.
Zlatan Ibrahimovic could return to the matchday squad after being rested on Saturday.
Phil Jones remains out, while Eric Bailly is a doubt.
In midfield, United will be without Michael Carrick and Marouane Fellaini.
Mourinho may rotate his side a little with the crucial Manchester derby on the horizon.
CSKA Moscow team news vs Man United
Alexei Berezutski and Georgi Milanov are both ruled out after breaking their legs last month.
Georgi Schennikov broke his ankle last month too and is also out.
Pontus Wernbloom is one of two players suspended for the Russian side. Wernbloom will be a big miss, having scored five goals in his last six.
Bibras Natcho is also suspended while Aleksandr Golovin is a booking away from a one-match ban.
Our prediction and bet for tonight : BOTH TO SCORE | 2. 00 |